Limits of Chromosome Compaction by Loop-Extruding Motors
During mitosis, human chromosomes are linearly compacted about 1000-fold by loop-extruding motors. Recent experiments have shown that condensins extrude DNA loops but in a “one-sided” manner. This contrasts with existing models, which predict that symmetric, “two-sided” loop extrusion accounts for m...
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society (APS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/126349 |