Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Through epigenetic and other regulatory functions, the histone deacetylase (HDAC) family of enzymes has emerged as a promising therapeutic target for central nervous system and other disorders. Here we report on the synthesis and functional characterization of new HDAC inhibitors based structurally...

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Bibliographic Details
Main Authors: Zhao, Wen-Ning, Ghosh, Balaram, Tyler, Marshall, Lalonde, Jasmin, Joseph, Nadine F., Kosaric, Nina, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: American Chemical Society (ACS) 2020
Online Access:https://hdl.handle.net/1721.1/126372

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https://hdl.handle.net/1721.1/126372

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