The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology
The membrane-anchored CX3CL1 is best known to exert its signaling function through binding its receptor CX3CR1. This study demonstrates a novel function that CX3CL1 exerts. CX3CL1 is sequentially cleaved by α-, β-, and γ-secretase, and the released CX3CL1 intracellular domain (CX3CL1-ICD) would tran...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Rockefeller University Press
2020
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| Online Access: | https://hdl.handle.net/1721.1/126401 |