High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

Type VI CRISPR-Cas systems contain programmable single-effector RNA-guided RNases, including Cas13b, one of the four known family members. Cas13b, which has been used for both RNA editing and nucleic acid detection, is unique among type VI CRISPR effectors in its linear domain architecture and CRISP...

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Bibliographic Details
Main Authors: Slaymaker, Ian, Mesa, Pablo, Kellner, Max J., Kannan, Soumya, Brignole, Edward J, Koob, Jeremy, Feliciano, Patricia Rosa, Stella, Stefano, Abudayyeh, Omar O., Gootenberg, Jonathan S, Strecker, Jonathan, Montoya, Guillermo, Zhang, Feng
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/126488

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https://hdl.handle.net/1721.1/126488

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