A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture
Fertilization triggers assembly of higher-order chromatin structure from a condensed maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops and domains have been detected in mouse zygotes by single-nucleus Hi-C (snHi-C), but not bulk Hi-C. It is therefore unclear when...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
EMBO
2020
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| Online Access: | https://hdl.handle.net/1721.1/126565 |