Minimal PAM specificity of a highly similar SpCas9 ortholog

Minimal PAM specificity of a highly similar SpCas9 ortholog

RNA-guided DNA endonucleases of the CRISPR-Cas system are widely used for genome engineering and thus have numerous applications in a wide variety of fields. CRISPR endonucleases, however, require a specific protospacer adjacent motif (PAM) flanking the target site, thus constraining their targetabl...

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Bibliographic Details
Main Authors: Chatterjee, Pranam, Jakimo, Noah, Jacobson, Joseph
Other Authors: Massachusetts Institute of Technology. Center for Bits and Atoms
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2020
Online Access:https://hdl.handle.net/1721.1/126805

Internet

https://hdl.handle.net/1721.1/126805

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