Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation
The de novo serine synthesis pathway is upregulated in many cancers. However, even cancer cells with increased serine synthesis take up large amounts of serine from the environment1, and we confirm that exogenous serine is needed for maximal proliferation of these cells. Here we show that even when...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/127671 |