Continuous Flow Synthesis of ACE Inhibitors From N-Substituted L-Alanine Derivatives
A strategy for the continuous flow synthesis of angiotensin converting enzyme (ACE) inhibitors is described. An optimization effort guided by in situ IR analysis resulted in a general amide coupling approach facilitated by N‐carboxyanhydride (NCA) activation that was further characterized by reactio...
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| Format: | Article |
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Wiley-VCH
2020
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| Online Access: | https://hdl.handle.net/1721.1/128240 |