Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution

Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution

In vitro prediction of physiologically relevant transport of therapeutic molecules across the microcirculation represents an intriguing opportunity to predict efficacy in human populations. On-chip microvascular networks (MVNs) show physiologically relevant values of molecular permeability, yet like...

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Bibliographic Details
Main Authors: Offeddu, Giovanni, Possenti, Luca, Loessberg‐Zahl, Joshua T, Zunino, Paolo, Roberts, John, Han, Xiaogang, Hickman, Dean, Knutson, Charles G, Kamm, Roger Dale
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/128270

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https://hdl.handle.net/1721.1/128270

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