Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model

Drug discovery and efficacy in cancer treatments are limited by the inability of pre-clinical models to predict successful outcomes in humans. Limitations remain partly due to their lack of a physiologic tumor microenvironment (TME), which plays a considerable role in drug delivery and tumor respons...

Full description

Bibliographic Details
Main Authors: Haase, Kristina Michelle, Offeddu, Giovanni, Gillrie, Mark Robert, Kamm, Roger Dale
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/128271