Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

Plasmodium parasites possess a protein with homology to Niemann-Pick Type C1 proteins (Niemann-Pick Type C1-Related protein, NCR1). We isolated parasites with resistance- conferring mutations in Plasmodium falciparum NCR1 (PfNCR1) during selections with three diverse small-molecule antimalarial comp...

Full description

Bibliographic Details
Main Authors: Istvan, Eva S, Das, Sudipta, Bhatnagar, Suyash, Beck, Josh R, Owen, Edward, Llinas, Manuel, Maddur Ganesan, Suresh, Niles, Jacquin, Winzeler, Elizabeth, Vaidya, Akhil B, Goldberg, Daniel E
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2020
Online Access:https://hdl.handle.net/1721.1/128765

Internet

https://hdl.handle.net/1721.1/128765

Similar Items