N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

Internal N 6-methyladenosine (m6A) modification is widespread in messenger RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) and Mettl14. To understand the role of m6A in development, we deleted Mettl14 in embryonic neural stem cells (NSCs) in a mouse model....

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Bibliographic Details
Main Authors: Wang, Yang, Li, Yue, Yue, Minghui, Wang, Jun, Wechsler-Reya, Robert J., Zhang, Zhaolei, Ogawa, Yuya, Kellis, Manolis, Duester, Gregg, Zhao, Jing Crystal
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/128892

Internet

https://hdl.handle.net/1721.1/128892

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