Reconstruction of Cell-type-Specific Interactomes at Single-Cell Resolution

The human interactome is instrumental in the systems-level study of the cell and the contextualization of disease-associated gene perturbations. However, reference organismal interactomes do not capture the cell-type-specific context in which proteins and modules preferentially act. Here, we introdu...

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Bibliographic Details
Main Authors: Mohammadi, Shahin, Davila Velderrain, Jose, Kellis, Manolis
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/129394