Joint profiling of DNA methylation and chromatin architecture in single cells
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both t...
| Principais autores: | , , , , , , , |
|---|---|
| Outros Autores: | |
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Springer Science and Business Media LLC
2021
|
| Acesso em linha: | https://hdl.handle.net/1721.1/129395 |