Joint profiling of DNA methylation and chromatin architecture in single cells
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both t...
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Bibliographic Details
| Main Authors: |
Li, Guoqiang,
Liu, Yaping,
Zhang, Yanxiao,
Kubo, Naoki,
Yu, Miao,
Fang, Rongxin,
Kellis, Manolis,
Ren, Bing |
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| Other Authors: |
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
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| Format: | Article
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| Language: | English |
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| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/129395
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