Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD cases and 166,145 controls from 70 ancestry-specific cohorts and ide...

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Những tác giả chính: Huckins, Laura M., Chatzinakos, Chris, Breen, Michael S., Hartmann, Jakob, Klengel, Torsten, da Silva Almeida, Ana C., Dobbyn, Amanda, Girdhar, Kiran, Hoffman, Gabriel E., Klengel, Claudia, Logue, Mark W., Lori, Adriana, Maihofer, Adam X., Morrison, Filomene G., Nguyen, Hoang T., Park, YongJin, Ruderfer, Douglas, Sloofman, Laura G., van Rooij, Sanne J.H., Baker, Dewleen G., Chen, Chia-Yen, Cox, Nancy, Duncan, Laramie E., Geyer, Mark A., Glatt, Stephen J., Im, Hae Kyung, Risbrough, Victoria B., Smoller, Jordan W., Stein, Dan J., Yehuda, Rachel, Liberzon, Israel, Koenen, Karestan C., Jovanovic, Tanja, Kellis, Manolis, Miller, Mark W., Bacanu, Silviu-Alin, Nievergelt, Caroline M., Buxbaum, Joseph D., Sklar, Pamela, Ressler, Kerry J., Stahl, Eli A., Daskalakis, Nikolaos P., PTSD Working Group of Psychiatric Genomics Consortium
Tác giả khác: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Elsevier BV 2021
Truy cập trực tuyến:https://hdl.handle.net/1721.1/129399

Internet

https://hdl.handle.net/1721.1/129399

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