Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors
Targeted polypharmacology provides an efficient method of treating diseases such as cancer with complex, multigenic causes provided that compounds with advantageous activity profiles can be discovered. Novel covalent TAK1 inhibitors were validated in cellular contexts for their ability to inhibit th...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
Elsevier BV
2021
|
Online Access: | https://hdl.handle.net/1721.1/129478 |