Covariate-Adaptive Optimization in Online Clinical Trials

The decision of how to allocate subjects to treatment groups is of great importance in experimental clinical trials for novel investigational drugs, a multibillion-dollar industry. Statistical power, the ability of an experiment to detect a positive treatment effect when one exists, depends in part...

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Bibliographic Details
Main Authors: Bertsimas, Dimitris J, Korolko, Nikita (Nikita E.), Weinstein, Alexander Michael
Other Authors: Sloan School of Management
Format: Article
Language:English
Published: Institute for Operations Research and the Management Sciences (INFORMS) 2021
Online Access:https://hdl.handle.net/1721.1/129812