Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1–4. Yet, we still do not know how enhancers regulate specific genes, and we lack general rules to predict enhancer–gene connec...

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Bibliographic Details
Main Authors: Fulco, Charles P., Nasser, Joseph, Jones, Thouis R., Munson, Glen, Bergman, Drew T., Subramanian, Vidya, Grossman, Sharon Rachel, Anyoha, Rockwell, Doughty, Benjamin R., Patwardhan, Tejal A., Nguyen, Tung Hoang, Kane, Michael A., Perez, Elizabeth M., Durand, Neva C., Lareau, Caleb A., Stamenova, Elena K., Aiden, Erez Lieberman, Lander, Eric Steven, Engreitz, Jesse Michael
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/129976

Internet

https://hdl.handle.net/1721.1/129976

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