Chromosome Intermingling: Mechanical Hotspots for Genome Regulation

Cells sense physical and chemical signals from their local microenvironment and transduce them to the nucleus to regulate genomic programs. In this review, we first discuss different modes of mechanotransduction to the nucleus. Then we highlight the role of the spatial organization of chromosomes fo...

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Bibliographic Details
Main Authors: Uhler, Caroline, Shivashankar, G.V.
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/130126