Chromosome Intermingling: Mechanical Hotspots for Genome Regulation
Cells sense physical and chemical signals from their local microenvironment and transduce them to the nucleus to regulate genomic programs. In this review, we first discuss different modes of mechanotransduction to the nucleus. Then we highlight the role of the spatial organization of chromosomes fo...
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| Format: | Article |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/130126 |
| _version_ | 1811098430217388032 |
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| author | Uhler, Caroline Shivashankar, G.V. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Uhler, Caroline Shivashankar, G.V. |
| author_sort | Uhler, Caroline |
| collection | MIT |
| description | Cells sense physical and chemical signals from their local microenvironment and transduce them to the nucleus to regulate genomic programs. In this review, we first discuss different modes of mechanotransduction to the nucleus. Then we highlight the role of the spatial organization of chromosomes for integrating these signals. In particular, we emphasize the importance of chromosome intermingling for gene regulation. We also discuss various geometric models and recent advances in microscopy and genomics that have allowed accessing these nanoscale chromosome intermingling regions. Taken together, the recent work summarized in this review culminates in the hypothesis that the chromosome intermingling regions are mechanical hotspots for genome regulation. Maintenance of such mechanical hotspots is crucial for cellular homeostasis, and alterations in them could be precursors for various cellular reprogramming events including diseases. |
| first_indexed | 2024-09-23T17:14:24Z |
| format | Article |
| id | mit-1721.1/130126 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T17:14:24Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1301262022-10-03T11:20:57Z Chromosome Intermingling: Mechanical Hotspots for Genome Regulation Uhler, Caroline Shivashankar, G.V. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Institute for Data, Systems, and Society Cells sense physical and chemical signals from their local microenvironment and transduce them to the nucleus to regulate genomic programs. In this review, we first discuss different modes of mechanotransduction to the nucleus. Then we highlight the role of the spatial organization of chromosomes for integrating these signals. In particular, we emphasize the importance of chromosome intermingling for gene regulation. We also discuss various geometric models and recent advances in microscopy and genomics that have allowed accessing these nanoscale chromosome intermingling regions. Taken together, the recent work summarized in this review culminates in the hypothesis that the chromosome intermingling regions are mechanical hotspots for genome regulation. Maintenance of such mechanical hotspots is crucial for cellular homeostasis, and alterations in them could be precursors for various cellular reprogramming events including diseases. DARPA (Contract W911NF-16-1-0551) NSF (Grant DMS-1651995) ONR (Grant N00014-17-1-2147) 2021-03-11T21:56:50Z 2021-03-11T21:56:50Z 2017-11 Article http://purl.org/eprint/type/JournalArticle 0962-8924 https://hdl.handle.net/1721.1/130126 Uhler, Caroline and G.V. Shivashankar. "Chromosome Intermingling: Mechanical Hotspots for Genome Regulation." Trends in Cell Biology 27, 11 (November 2017): P810-819. © 2017 Elsevier Ltd https://doi.org/10.1016/j.tcb.2017.06.005 Trends in Cell Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Prof. Uhler via Phoebe Ayers |
| spellingShingle | Uhler, Caroline Shivashankar, G.V. Chromosome Intermingling: Mechanical Hotspots for Genome Regulation |
| title | Chromosome Intermingling: Mechanical Hotspots for Genome Regulation |
| title_full | Chromosome Intermingling: Mechanical Hotspots for Genome Regulation |
| title_fullStr | Chromosome Intermingling: Mechanical Hotspots for Genome Regulation |
| title_full_unstemmed | Chromosome Intermingling: Mechanical Hotspots for Genome Regulation |
| title_short | Chromosome Intermingling: Mechanical Hotspots for Genome Regulation |
| title_sort | chromosome intermingling mechanical hotspots for genome regulation |
| url | https://hdl.handle.net/1721.1/130126 |
| work_keys_str_mv | AT uhlercaroline chromosomeinterminglingmechanicalhotspotsforgenomeregulation AT shivashankargv chromosomeinterminglingmechanicalhotspotsforgenomeregulation |