Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical...

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Bibliographic Details
Main Authors: Van Egeren, Debra, Novokhodko, Alexander, Stoddard, Madison, Tran, Uyen, Zetter, Bruce, Rogers, Michael, Pentelute, Bradley L., Carlson, Jonathan M., Hixon, Mark, Joseph-McCarthy, Diane, Chakravarty, Arijit
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Published: Public Library of Science (PLoS) 2021
Online Access:https://hdl.handle.net/1721.1/130548

Internet

https://hdl.handle.net/1721.1/130548

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