Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical...

Full description

Bibliographic Details
Main Authors:	Van Egeren, Debra, Novokhodko, Alexander, Stoddard, Madison, Tran, Uyen, Zetter, Bruce, Rogers, Michael, Pentelute, Bradley L., Carlson, Jonathan M., Hixon, Mark, Joseph-McCarthy, Diane, Chakravarty, Arijit
Other Authors:	Massachusetts Institute of Technology. Department of Chemistry
Format:	Article
Published:	Public Library of Science (PLoS) 2021
Online Access:	https://hdl.handle.net/1721.1/130548

Similar Items

Controlling long-term SARS-CoV-2 infections can slow viral evolution and reduce the risk of treatment failure
by: Debra Van Egeren, et al.
Published: (2021-11-01)

Rapid relaxation of pandemic restrictions after vaccine rollout favors growth of SARS-CoV-2 variants: A model-based analysis.
by: Debra Van Egeren, et al.
Published: (2021-01-01)

Vaccines Alone Cannot Slow the Evolution of SARS-CoV-2
by: Debra Van Egeren, et al.
Published: (2023-04-01)

Computational identification of antibody-binding epitopes from mimotope datasets
by: Rang Li, et al.
Published: (2024-02-01)

Antibody escape, the risk of serotype formation, and rapid immune waning: Modeling the implications of SARS-CoV-2 immune evasion.
by: Catherine Albright, et al.
Published: (2023-01-01)

Looking under the lamp-post: quantifying the performance of contact tracing in the United States during the SARS-CoV-2 pandemic
by: Henry Bayly, et al.
Published: (2024-02-01)

No magic bullet: Limiting in-school transmission in the face of variable SARS-CoV-2 viral loads
by: Debra Van Egeren, et al.
Published: (2022-12-01)

Challenges of Learning to Escape Evolutionary Traps
by: Alison L. Greggor, et al.
Published: (2019-10-01)

Machine learning for the identification of respiratory viral attachment machinery from sequences data.
by: Kenji C Walker, et al.
Published: (2023-01-01)

Machine learning for the identification of respiratory viral attachment machinery from sequences data
by: Kenji C. Walker, et al.
Published: (2023-01-01)

Evolutionary escape from the Rubisco activase requirement
by: Guo, Zhijun
Published: (2019)

In the long shadow of our best intentions: Model-based assessment of the consequences of school reopening during the COVID-19 pandemic.
by: Kaitlyn E Johnson, et al.
Published: (2021-01-01)

Spike nanoparticles: From design to biomedical applications
by: Xiaohui Wang, et al.
Published: (2024-01-01)

Escape From X-Chromosome Inactivation: An Evolutionary Perspective
by: Bronwyn J. Posynick, et al.
Published: (2019-10-01)

The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression.
by: Becca Asquith
Published: (2008-01-01)

Can normalization methods allow escape from the doppelgänger effect in biomedical data?
by: Guo, Zexi
Published: (2023)

Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike.
by: Xiaodi Yu, et al.
Published: (2023-05-01)

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
by: Yiska Weisblum, et al.
Published: (2020-10-01)

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.
by: Marta Alenquer, et al.
Published: (2021-08-01)

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
by: Marta Alenquer, et al.
Published: (2021-08-01)

Evolutionary models predict potential mechanisms of escape from mutational meltdown
by: Claudia Bank, et al.
Published: (2022-08-01)

Multi-objective evolutionary algorithms of spiking neural networks
by: Saleh, Abdulrazak Yahya
Published: (2015)

Multi-objective evolutionary algorithms of spiking neural networks /
by: Abdulrazak Yahya Saleh, 1974-, author 647485
Published: (2015)

Multi-objective evolutionary algorithms of spiking neural networks /
by: Abdulrazak Yahya Saleh, 1974-, author 647485, et al.
Published: (2015)

Beyond the new normal: Assessing the feasibility of vaccine-based suppression of SARS-CoV-2.
by: Madison Stoddard, et al.
Published: (2021-01-01)

Evolutionary design of explainable algorithms for biomedical image segmentation
by: Kévin Cortacero, et al.
Published: (2023-11-01)

Model for the induction of spike timing-dependent plasticity by pre- and postsynaptic spike trains
by: Giordano Nicholas, et al.
Published: (2010-07-01)

Molecular Evolutionary Analyses of the Spike Protein Gene and Spike Protein in the SARS-CoV-2 Omicron Subvariants
by: Norika Nagasawa, et al.
Published: (2023-09-01)

Evolutionary change in the development of enabling technologies : a strategic perspective for advanced systems design
by: McCarthy, Robert J
Published: (2005)

The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
by: Dandan Tian, et al.
Published: (2021-11-01)

Implication of SARS-CoV-2 Immune Escape Spike Variants on Secondary and Vaccine Breakthrough Infections
by: Liyana Ahmad
Published: (2021-11-01)

Evolutionary Dynamics of Indels in SARS-CoV-2 Spike Glycoprotein
by: R Shyama Prasad Rao, et al.
Published: (2021-12-01)

Spike Neural Network Learning Algorithm Based on an Evolutionary Membrane Algorithm
by: Chuang Liu, et al.
Published: (2021-01-01)

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
by: Roberta Marzi, et al.
Published: (2023-01-01)

Omicron Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 Recognition and Antibody Escape
by: Hin Hark Gan, et al.
Published: (2022-06-01)

Evolutionary dynamics of hyperbolic language
by: Madison S. Krieger
Published: (2023-02-01)

Evolutionary dynamics of hyperbolic language.
by: Madison S Krieger
Published: (2023-02-01)

Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation
by: Rodriguez-Beltran, J, et al.
Published: (2018)

A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid
by: Laura Perlaza-Jiménez, et al.
Published: (2022-08-01)

Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategy
by: Madison Stoddard, et al.
Published: (2023-04-01)