Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followed by transaminatio...

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Bibliographic Details
Main Authors: Ahlqvist, Grace P., McGeough, Catherine P., Senanayake, Chris, Armstrong, Joseph D., Yadaw, Ajay, Roy, Sarabindu, Ahmad, Saeed, Snead, David R., Jamison, Timothy F
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: American Chemical Society (ACS) 2021
Online Access:https://hdl.handle.net/1721.1/130900

Internet

https://hdl.handle.net/1721.1/130900

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