Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasm...

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Detalhes bibliográficos
Principais autores: Filbin, Michael R., Mehta, Arnav, Schneider, Alexis M., Kays, Kyle R., Guess, Jamey R., Gentili, Matteo, Fenyves, Bánk G., Charland, Nicole C., Gonye, Anna L.K., Gushterova, Irena, Khanna, Hargun K., LaSalle, Thomas J., Lavin-Parsons, Kendall M., Lilley, Brendan M., Lodenstein, Carl L., Manakongtreecheep, Kasidet, Margolin, Justin D., McKaig, Brenna N., Rojas-Lopez, Maricarmen, Russo, Brian C., Sharma, Nihaarika, Tantivit, Jessica, Thomas, Molly F., Gerszten, Robert E., Heimberg, Graham S., Hoover, Paul J., Lieb, David J., Lin, Brian, Ngo, Debby, Pelka, Karin, Reyes, Miguel, Smillie, Chris S, Waghray, Avinash, Wood, Thomas E., Zajac, Amanda S., Jennings, Lori L., Grundberg, Ida, Bhattacharyya, Roby P., Parry, Blair Alden, Villani, Alexandra-Chloé, Sade-Feldman, Moshe, Hacohen, Nir, Goldberg, Marcia B.
Outros Autores: Massachusetts Institute of Technology. Department of Biological Engineering
Formato: Artigo
Idioma:English
Publicado em: Elsevier BV 2021
Acesso em linha:https://hdl.handle.net/1721.1/131124

Internet

https://hdl.handle.net/1721.1/131124

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