Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical. Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates to fill such a role, but their challenging synthesis limits...

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Bibliographic Details
Main Authors: Li, Chengxi, Callahan, Alex J., Simon, Mark, Totaro, Kyle A., Mijalis, Alexander James, Phadke, Kruttika-Suhas, Zhang, Genwei, Hartrampf, Nina, Schissel, Carly K., Zhou, Ming, Zong, Hong, Hanson, Gunnar J., Loas, Andrei Ioan, Pohl, Nicola L. B., Verhoeven, David E., Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/131157

Internet

https://hdl.handle.net/1721.1/131157

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