Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model

Show other versions (3)

Epigenetic dysregulation is hypothesized to play a role in the observed association between inflammatory bowel disease (IBD) and colon tumor development. In the present work, DNA methylome, hydroxymethylome, and transcriptome analyses were conducted in proximal colon tissues harvested from the <i...

Full description

Bibliographic Details
Main Authors:	Han, Qiyuan, Kono, Thomas J. Y., Knutson, Charles G., Parry, Nicola M., Seiler, Christopher L., Fox, James G., Tannenbaum, Steven R., Tretyakova, Natalia Y.
Format:	Article
Published:	Multidisciplinary Digital Publishing Institute 2021
Online Access:	https://hdl.handle.net/1721.1/131312

Similar Items

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model
by: Han, Qiyuan, et al.
Published: (2022)

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model
by: Han, Qiyuan, et al.
Published: (2021)

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model
by: Han, Qiyuan, et al.
Published: (2022)

Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2−/−Il10−/−gpt delta mice is influenced by sex
by: Ge, Zhongming, et al.
Published: (2020)

Proposed grading scheme for inflammatory bowel disease in ferrets and correlation with clinical signs
by: Cazzini, Paola, et al.
Published: (2021)

Serum Metabolomics in a Helicobacter hepaticus Mouse Model of Inflammatory Bowel Disease Reveal Important Changes in the Microbiome, Serum Peptides, and Intermediary Metabolism
by: Lu, Kun, et al.
Published: (2014)

Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10−/− Mice
by: Mannion, Anthony, et al.
Published: (2021)

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease
by: Knutson, Charles G. F., et al.
Published: (2015)

A Wavelet-Based Approach Reveals Host-Cell-Type-Specific Multi-omics Networks in Inflammatory Bowel Disease
by: Chang, Stephanie, et al.
Published: (2024)

Helicobacter hepaticus cytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2‐deficient mice
by: Ge, Zhongming, et al.
Published: (2019)

Hyperplasia of thymic gland
by: Lee, Y.M., et al.
Published: (1996)

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer
by: Conaway, E A, et al.
Published: (2018)

Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota
by: Whary, Mark T., et al.
Published: (2015)

Quantitative Proteogenomic Characterization of Inflamed Murine Colon Tissue Using an Integrated Discovery, Verification, and Validation Proteogenomic Workflow
by: Rajczewski, Andrew T., et al.
Published: (2022)

Serum Inflammatory Markers and Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases
by: Ananthakrishnan, Ashwin N., et al.
Published: (2016)

Primary small Bowel volvulus.
by: Paras, KP, et al.
Published: (2013)

Prevalence of osteoporosis in Malaysian patients with inflammatory bowel disease
by: Hilmi, S.I., et al.
Published: (2010)

Inflammatory bowel disease: a survey of the epidemiology in Asia
by: Goh, K.L., et al.
Published: (2009)

Probiotic vesicles as supplement for inflammatory bowel disease treatment
by: Pun, Song Yi
Published: (2023)

Association between inflammatory bowel disease gene 5 (IBD5) and interleukin‐23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease
by: Chua, Kek Heng, et al.
Published: (2012)

Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease
by: Bhosle, Amrisha, et al.
Published: (2024)

Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease
by: Ananthakrishnan, Ashwin N., et al.
Published: (2016)

Quantitative spectroscopy for detection of cervical dysplasia
by: Mirković, Jelena, Ph. D. Massachusetts Institute of Technology
Published: (2010)

Thromboprophylaxis Is Associated With Reduced Post-hospitalization Venous Thromboembolic Events in Patients With Inflammatory Bowel Diseases
by: Ananthakrishnan, Ashwin N., et al.
Published: (2016)

Metabolic nanoregulator remodels gut microenvironment for treatment of inflammatory bowel disease
by: Xu, Ting, et al.
Published: (2024)

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease
by: Ermann, J., et al.
Published: (2017)

Asian consensus on irritable bowel syndrome
by: Gwee, Kok-Ann, et al.
Published: (2010)

Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
by: Fox, James G., et al.
Published: (2014)

The development of colitis in Il10−/− mice is dependent on IL-22
by: Gunasekera, Dilini C, et al.
Published: (2021)

The development of colitis in Il10−/− mice is dependent on IL-22
by: Gunasekera, Dilini C., et al.
Published: (2022)

Gastric dysplasia : a clinical and pathological analysis.
by: Lee, Jocelyn Shi Ting.
Published: (2013)

Detecting cervical dysplasia with quantitative spectroscopic imaging
by: Lau, Condon
Published: (2017)

Effect of anatomy on spectroscopic detection of cervical dysplasia
by: Mirkovic, Jelena, et al.
Published: (2010)

Oestrogen and progesterone receptors in the uterine wall of bitches with cystic endometrial hyperplasia/pyometra
by: Dhaliwal, G. K., et al.
Published: (1999)

Helicobacter cinaedi Induced Typhlocolitis in Rag-2-Deficient Mice
by: Shen, Zeli, et al.
Published: (2017)

Development of probiotic nanovesicles for oral delivery in inflammatory bowel disease (IBD) treatment
by: Lin, Xiang
Published: (2024)

Non-Invasive Mapping of the Gastrointestinal Microbiota Identifies Children with Inflammatory Bowel Disease
by: Papa, Eli, et al.
Published: (2012)

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease
by: Zhang, Sufeng, et al.
Published: (2022)

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease
by: Zhang, Sufeng, et al.
Published: (2021)

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients
by: Hall, Andrew Brantley, et al.
Published: (2018)