Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles

Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles

The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers, including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to target directly, we considered whether metabolic changes driven by activated STAT3 could provide a therapeutic opportu...

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Bibliographic Details
Main Authors: Tošić, Isidora, Heppler, Lisa N, Egusquiaguirre, Susana P, Boehnke, Natalie, Correa, Santiago, Costa, Daniel F, Moore, Elizabeth A Grossman, Pal, Sharmistha, Richardson, Douglas S, Ivanov, Alexander R, Haas-Kogan, Daphne A, Nomura, Daniel K, Hammond, Paula T, Frank, David A
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: American Association for Cancer Research (AACR) 2021
Online Access:https://hdl.handle.net/1721.1/132701

Internet

https://hdl.handle.net/1721.1/132701

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