A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis
© 2020 Wiley Periodicals LLC Stapled α-helical RIR (Rev1-interacting region) peptides of DNA POL κ bind more effectively to the RIR-interface of the C-terminal recruitment domain of the translesion synthesis DNA polymerase Rev1 than unstapled peptide. The tightest-binding stapled peptide translocate...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/132710 |
| _version_ | 1811083797964259328 |
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| author | Chatterjee, Nimrat D'Souza, Sanjay Shabab, Mohammad Harris, Cynthia A Hilinski, Gerard J Verdine, Gregory L Walker, Graham C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Chatterjee, Nimrat D'Souza, Sanjay Shabab, Mohammad Harris, Cynthia A Hilinski, Gerard J Verdine, Gregory L Walker, Graham C |
| author_sort | Chatterjee, Nimrat |
| collection | MIT |
| description | © 2020 Wiley Periodicals LLC Stapled α-helical RIR (Rev1-interacting region) peptides of DNA POL κ bind more effectively to the RIR-interface of the C-terminal recruitment domain of the translesion synthesis DNA polymerase Rev1 than unstapled peptide. The tightest-binding stapled peptide translocates into cells and enhances the cytotoxicity of DNA damaging agents while reducing mutagenesis. Drugs with these characteristics could potentially serve as adjuvants to improve chemotherapy and reduce acquired resistance by inhibiting Rev1-dependent mutagenic translesion synthesis. |
| first_indexed | 2024-09-23T12:39:28Z |
| format | Article |
| id | mit-1721.1/132710 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:39:28Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1327102024-05-31T20:07:35Z A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis Chatterjee, Nimrat D'Souza, Sanjay Shabab, Mohammad Harris, Cynthia A Hilinski, Gerard J Verdine, Gregory L Walker, Graham C Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT © 2020 Wiley Periodicals LLC Stapled α-helical RIR (Rev1-interacting region) peptides of DNA POL κ bind more effectively to the RIR-interface of the C-terminal recruitment domain of the translesion synthesis DNA polymerase Rev1 than unstapled peptide. The tightest-binding stapled peptide translocates into cells and enhances the cytotoxicity of DNA damaging agents while reducing mutagenesis. Drugs with these characteristics could potentially serve as adjuvants to improve chemotherapy and reduce acquired resistance by inhibiting Rev1-dependent mutagenic translesion synthesis. 2021-10-04T19:13:57Z 2021-10-04T19:13:57Z 2020-07 2020-05 2021-10-04T17:56:14Z Article http://purl.org/eprint/type/JournalArticle 1098-2280 https://hdl.handle.net/1721.1/132710 Chatterjee, Nimrat, D'Souza, Sanjay, Shabab, Mohammad, Harris, Cynthia A, Hilinski, Gerard J et al. 2020. "A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis." Environmental and Molecular Mutagenesis, 61 (8). en 10.1002/EM.22395 Environmental and Molecular Mutagenesis Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Chatterjee, Nimrat D'Souza, Sanjay Shabab, Mohammad Harris, Cynthia A Hilinski, Gerard J Verdine, Gregory L Walker, Graham C A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis |
| title | A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis |
| title_full | A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis |
| title_fullStr | A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis |
| title_full_unstemmed | A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis |
| title_short | A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis |
| title_sort | stapled pol κ peptide targets rev1 to inhibit mutagenic translesion synthesis |
| url | https://hdl.handle.net/1721.1/132710 |
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