The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE...

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Main Authors: Botti-Lodovico, Yolanda, Nair, Parvathy, Nosamiefan, Dolo, Stremlau, Matthew, Schaffner, Stephen, Agignoae, Sebastian V., Aiyepada, John Oke, Ajogbasile, Fehintola V., Akpede, George O., Alhasan, Foday, Andersen, Kristian G., Asogun, Danny A., Ayodeji, Oladele Oluwafemi, Badiane, Aida S., Barnes, Kayla, Bauer, Matthew R., Bell-Kareem, Antoinette, Benard, Muoebonam Ekene, Benevolence, Ebo Ohomoime, Blessing, Osiemi, Boehm, Chloe K., Boisen, Matthew L., Bond, Nell G., Branco, Luis M., Butts, Michael J., Carter, Amber, Colubri, Andres, Deme, Awa B., DeRuff, Katherine C., Diédhiou, Younousse, Edamhande, Akhilomen Patience, Elhamoumi, Siham, Engel, Emily J., Eromon, Philomena, Fallah, Mosoka, Folarin, Onikepe A., Fry, Ben, Garry, Robert, Gaye, Amy, Gbakie, Michael, Gevao, Sahr M., Gionet, Gabrielle, Gladden-Young, Adrianne, Goba, Augustine, Gomis, Jules Francois, Happi, Anise N., Houghton, Mary, Ihekwuazu, Chikwe, Iruolagbe, Christopher Ojemiega, Jackson, Jonathan, Jalloh, Simbirie, Johnson, Jeremy, Kanneh, Lansana, Kayode, Adeyemi, Kemball, Molly, Kingsley, Ojide Chiedozie, Koroma, Veronica, Kotliar, Dylan, Mehta, Samar, Metsky, Hayden C., Michael, Airende, Mirhashemi, Marzieh Ezzaty, Modjarrad, Kayvon, Momoh, Mambu, Myhrvold, Cameron A., Naregose, Okonofua Grace, Ndiaye, Tolla, Ndiaye, Mouhamadou, Ndiaye, Aliou, Normandin, Erica, Odia, Ikponmwosa, Oguzie, Judith Uche, Okogbenin, Sylvanus A., Okokhere, Peter O., Okolie, Johnson, Olawoye, Idowu B., Olumade, Testimony J., Oluniyi, Paul E., Omoregie, Omigie, Park, Daniel J., Paye, Mariétou Faye, Petros, Brittany A., Philippakis, Anthony A., Priscilla, Abechi, Ricks, Alan, Rimoin, Anne, Sandi, John Demby, Schieffelin, John S., Schreiber, Monica, Seck, Mame Cheikh, Siddiqui, Sameed, Siddle, Katherine, Smither, Allison R., Sy, Mouhamad, Sy, Ngayo, Tomkins-Tinch, Christopher H., Tomori, Oyewale, Ugwu, Chinedu, Uwanibe, Jessica N., Uyigue, Eghosasere Anthonia, Victoria, Dada Ireti, Vinzé, Anika, Vodzak, Megan E., Welch, Nicole, Wurie, Haja Isatta, Zoumarou, Daba, Grant, Donald S., Ndiaye, Daouda, MacInnis, Bronwyn, Sabeti, Pardis C., Happi, Christian
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:English
Published: MDPI AG 2021
Online Access:https://hdl.handle.net/1721.1/132714