Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

The nuclear lamina—a meshwork of intermediate filaments termed lamins—is primarily responsible for the mechanical stability of the nucleus in multicellular organisms. However, structural-mechanical characterization of lamin filaments assembled in situ remains elusive. Here, we apply an integrative a...

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Bibliographic Details
Main Authors: Sapra, K Tanuj, Qin, Zhao, Dubrovsky-Gaupp, Anna, Aebi, Ueli, Müller, Daniel J, Buehler, Markus J, Medalia, Ohad
Other Authors: Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/132718