Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

<p>We identified potent, functionalisable BMX inhibitors and revealed their covalent mode of binding to BMX by X-ray crystallography.</p>

Bibliografiska uppgifter
Huvudupphovsmän:	Seixas, João D, Sousa, Bárbara B, Marques, Marta C, Guerreiro, Ana, Traquete, Rui, Rodrigues, Tiago, Albuquerque, Inês S, Sousa, Marcos FQ, Lemos, Ana R, Sousa, Pedro MF, Bandeiras, Tiago M, Wu, Di, Doyle, Shelby K, Robinson, Carol V, Koehler, Angela N, Corzana, Francisco, Matias, Pedro M, Bernardes, Gonçalo JL
Övriga upphovsmän:	Koch Institute for Integrative Cancer Research at MIT
Materialtyp:	Artikel
Språk:	English
Publicerad:	Royal Society of Chemistry (RSC) 2022
Länkar:	https://hdl.handle.net/1721.1/133096.2

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors av Seixas, João D, Sousa, Bárbara B, Marques, Marta C, Guerreiro, Ana, Traquete, Rui, Rodrigues, Tiago, Albuquerque, Inês S, Sousa, Marcos FQ, Lemos, Ana R, Sousa, Pedro MF, Bandeiras, Tiago M, Wu, Di, Doyle, Shelby K, Robinson, Carol V, Koehler, Angela N, Corzana, Francisco, Matias, Pedro M, Bernardes, Gonçalo JL

Publicerad 2021

Hämta fulltext

Artikel