Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

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Regulatory networks that maintain functional, differentiated cell states are often dysregulated in tumor development. Here, we use single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma (LUAD). We identify an epigenomic continuum representing loss of c...

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Bibliographic Details
Main Authors: LaFave, Lindsay M, Kartha, Vinay K, Ma, Sai, Meli, Kevin, Del Priore, Isabella, Lareau, Caleb, Naranjo, Santiago, Westcott, Peter MK, Duarte, Fabiana M, Sankar, Venkat, Chiang, Zachary, Brack, Alison, Law, Travis, Hauck, Haley, Okimoto, Annalisa, Regev, Aviv, Buenrostro, Jason D, Jacks, Tyler
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/133249

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https://hdl.handle.net/1721.1/133249

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