Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

© 2020 National Academy of Sciences. All rights reserved. Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis in many cancer types. However, the condition causes cellular stress and cell cycle delays, foremost in G1 and S phase. Here, we investigate ho...

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Bibliographic Details
Main Authors: Replogle, John Michael, Zhou, Wen, Amaro, Adrianna E, McFarland, James M, Villalobos-Ortiz, Mariana, Ryan, Jeremy, Letai, Anthony, Yilmaz, Omer, Sheltzer, Jason, Lippard, Stephen J, Ben-David, Uri, Amon, Angelika
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/133334

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https://hdl.handle.net/1721.1/133334

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