High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

Macrophages are plastic and, in response to different local stimuli, can polarize toward multi-dimensional spectrum of phenotypes, including the pro-inflammatory M1-like and the anti-inflammatory M2-like states. Using a high-throughput phenotypic screen in a library of ~4000 FDA-approved drugs, bioa...

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Bibliographic Details
Main Authors: Hu, Guangan, Su, Yang, Kang, Byong Ha, Fan, Zhongqi, Dong, Ting, Brown, Douglas R, Cheah, Jaime, Wittrup, Karl Dane, Chen, Jianzhu
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/133434

Internet

https://hdl.handle.net/1721.1/133434

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