Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

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© 2020 The Authors In a companion paper, a two-step developability assessment is presented to rapidly evaluate low-cost formulations (multi-dose, aluminum-adjuvanted) for new subunit vaccine candidates. As a case study, a non-replicating rotavirus (NRRV) recombinant protein antigen P[4] was found to...

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Bibliographic Details
Main Authors: Kaur, Kawaljit, Xiong, Jian, Sawant, Nishant, Agarwal, Sanjeev, Hickey, John M, Holland, David A, Mukhopadhyay, Tarit K, Brady, Joseph R, Dalvie, Neil C., Tracey, Mary Kate, Love, Kerry R., Love, J. Christopher, Weis, David D, Joshi, Sangeeta B, Volkin, David B
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/133452.2

Internet

https://hdl.handle.net/1721.1/133452.2

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