CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia

CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia

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© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Therapies employing chimeric antigen receptor T cells (CAR-T cells) targeting tumour-associated antigens (TAAs) can lead to on-target–off-tumour toxicity and to resistance, owing to TAA expression in normal tissues and to TAA...

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Bibliographic Details
Main Authors: Xie, Guozhu, Ivica, Nikola A, Jia, Bin, Li, Yingzhong, Dong, Han, Liang, Yong, Brown, Douglas, Romee, Rizwan, Chen, Jianzhu
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/133479

Internet

https://hdl.handle.net/1721.1/133479

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