Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway

© 2020, The Author(s). Antibiotic biosynthetic gene clusters (BGCs) produce bioactive metabolites that impart a fitness advantage to their producer, providing a mechanism for natural selection. This selection drives antibiotic evolution and adapts BGCs for expression in different organisms, potentia...

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Bibliographic Details
Main Authors: Johnston, Chad W, Badran, Ahmed H, Collins, James J
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/133496