In situ genome sequencing resolves DNA sequence and structure in intact biological samples

In situ genome sequencing resolves DNA sequence and structure in intact biological samples

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Understanding genome organization requires integration of DNA sequence and three-dimensional spatial context; however, existing genome-wide methods lack either base pair sequence resolution or direct spatial localization. Here, we describe in situ genome sequencing (IGS), a method for simultaneously...

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Bibliographic Details
Main Authors: Payne, Andrew C, Chiang, Zachary D, Reginato, Paul L, Mangiameli, Sarah M, Murray, Evan M, Yao, Chun-Chen, Markoulaki, Styliani, Earl, Andrew S, Labade, Ajay S, Jaenisch, Rudolf, Church, George M, Boyden, Edward S, Buenrostro, Jason D, Chen, Fei
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021
Online Access:https://hdl.handle.net/1721.1/133498

Internet

https://hdl.handle.net/1721.1/133498

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