Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model

Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid Dexamethasone (Dex) on these responses. Design: Bovine...

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Bibliographic Details
Main Authors: Black, Rebecca Mae, Wang, Yang, Struglics, André, Lorenzo, Pilar, Tillgren, Viveka, Rydén, Martin, Grodzinsky, Alan J, Önnerfjord, Patrik
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/133524