LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

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© 2020 National Academy of Sciences. All rights reserved. LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable...

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Bibliografske podrobnosti
Main Authors: Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J, Durbin, Adam D, Zimmerman, Mark W, Powers, John T, Missios, Pavlos, Ross, Kenneth N, Perez-Atayde, Antonio R, Bulyk, Martha L, Young, Richard A, Daley, George Q, Look, A Thomas
Format: Article
Jezik:English
Izdano: Proceedings of the National Academy of Sciences 2021
Online dostop:https://hdl.handle.net/1721.1/133977

Internet

https://hdl.handle.net/1721.1/133977

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