Stress-induced nuclear condensation of NELF drives transcriptional downregulation

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

Show other versions (1)

In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II elongation. Here we report that NELF rapidly forms nuclear...

Full description

Bibliographic Details
Main Authors: Rawat, Prashant, Boehning, Marc, Hummel, Barbara, Aprile-Garcia, Fernando, Pandit, Anwit S, Eisenhardt, Nathalie, Khavaran, Ashkan, Niskanen, Einari, Vos, Seychelle M, Palvimo, Jorma J, Pichler, Andrea, Cramer, Patrick, Sawarkar, Ritwick
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134062

Internet

https://hdl.handle.net/1721.1/134062

Similar Items