PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer's disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocytic defect in APOE4 astrocytes compared with their isogenic...

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Main Authors: Narayan, Priyanka, Sienski, Grzegorz, Bonner, Julia M, Lin, Yuan-Ta, Seo, Jinsoo, Baru, Valeriya, Haque, Aftabul, Milo, Blerta, Akay, Leyla A, Graziosi, Agnese, Freyzon, Yelena, Landgraf, Dirk, Hesse, William R, Valastyan, Julie, Barrasa, M Inmaculada, Tsai, Li-Huei, Lindquist, Susan
其他作者: Whitehead Institute for Biomedical Research
格式: 文件
语言:English
出版: Elsevier BV 2021
在线阅读:https://hdl.handle.net/1721.1/134090

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https://hdl.handle.net/1721.1/134090

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