Evidence for secondary-variant genetic burden and non-random distribution across biological modules in a recessive ciliopathy

Evidence for secondary-variant genetic burden and non-random distribution across biological modules in a recessive ciliopathy

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© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. The influence of genetic background on driver mutations is well established; however, the mechanisms by which the background interacts with Mendelian loci remain unclear. We performed a systematic secondary-variant burde...

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Main Authors: Kousi, Maria, Söylemez, Onuralp, Ozanturk, Aysegül, Mourtzi, Niki, Akle, Sebastian, Jungreis, Irwin, Muller, Jean, Cassa, Christopher A, Brand, Harrison, Mokry, Jill Anne, Wolf, Maxim Y, Sadeghpour, Azita, McFadden, Kelsey, Lewis, Richard A, Talkowski, Michael E, Dollfus, Hélène, Kellis, Manolis, Davis, Erica E, Sunyaev, Shamil R, Katsanis, Nicholas
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/134169

Internet

https://hdl.handle.net/1721.1/134169

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