Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

© 2020 Elsevier Inc. Obesity is an intrinsic driver of PDAC in mice, leading to a remodeling of beta cells to increase CCK secretion and playing a role early in pancreatic cancer development that can be intercepted by weight loss.

Bibliographic Details
Main Authors: Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B, Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A, Dias Costa, Andressa, Nowak, Jonathan A, Chang, Daniel T, Dunne, Richard F, Hezel, Aram F, Koong, Albert C, Wilhelm, Joshua J, Bellin, Melena D, Nylander, Vibe, Gloyn, Anna L, McCarthy, Mark I, Kibbey, Richard G, Krishnaswamy, Smita, Wolpin, Brian M, Jacks, Tyler, Fuchs, Charles S, Muzumdar, Mandar Deepak
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134176

Internet

https://hdl.handle.net/1721.1/134176

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