Spurious regulatory connections dictate the expression‐fitness landscape of translation factors

During steady-state cell growth, individual enzymatic fluxes can be directly inferred from growth rate by mass conservation, but the inverse problem remains unsolved. Perturbing the flux and expression of a single enzyme could have pleiotropic effects that may or may not dominate the impact on cell...

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Bibliographic Details
Main Authors: Lalanne, Jean-Benoît, Parker, Darren J, Li, Gene-Wei
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: EMBO 2021
Online Access:https://hdl.handle.net/1721.1/134184