Low-N protein engineering with data-efficient deep learning

Protein engineering has enormous academic and industrial potential. However, it is limited by the lack of experimental assays that are consistent with the design goal and sufficiently high throughput to find rare, enhanced variants. Here we introduce a machine learning-guided paradigm that can use a...

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Bibliographic Details
Main Authors: Biswas, Surojit, Khimulya, Grigory, Alley, Ethan C, Esvelt, Kevin M, Church, George M
Other Authors: Massachusetts Institute of Technology. Media Laboratory
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/134193