Low-N protein engineering with data-efficient deep learning
Protein engineering has enormous academic and industrial potential. However, it is limited by the lack of experimental assays that are consistent with the design goal and sufficiently high throughput to find rare, enhanced variants. Here we introduce a machine learning-guided paradigm that can use a...
Main Authors: | Biswas, Surojit, Khimulya, Grigory, Alley, Ethan C, Esvelt, Kevin M, Church, George M |
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Other Authors: | Massachusetts Institute of Technology. Media Laboratory |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2021
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Online Access: | https://hdl.handle.net/1721.1/134193 |
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