Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

© 2020 The Authors A two-step developability assessment workflow is described to screen variants of recombinant protein antigens under various formulation conditions to rapidly identify stable, aluminum-adjuvanted, multi-dose vaccine candidates. For proof-of-concept, a series of sequence variants of...

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Bibliographic Details
Main Authors: Sawant, Nishant, Kaur, Kawaljit, Holland, David A, Hickey, John M, Agarwal, Sanjeev, Brady, Joseph R, Dalvie, Neil C, Tracey, Mary Kate, Velez-Suberbie, M Lourdes, Morris, Stephen A, Jacob, Shaleem I, Bracewell, Daniel G, Mukhopadhyay, Tarit K, Love, Kerry R, Love, J Christopher, Joshi, Sangeeta B, Volkin, David B
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134368

Internet

https://hdl.handle.net/1721.1/134368

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