Quantifying the Stability of Coupled Genetic and Epigenetic Switches With Variational Methods

The Waddington landscape provides an intuitive metaphor to view development as a ball rolling down the hill, with distinct phenotypes as basins and differentiation pathways as valleys. Since, at a molecular level, cell differentiation arises from interactions among the genes, a mathematical definiti...

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Bibliographic Details
Main Authors: Sood, Amogh, Zhang, Bin
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Frontiers Media SA 2021
Online Access:https://hdl.handle.net/1721.1/134372